D2003-07

Patent Pending

This technolgy may be useful as a therapeutic and/or as a protomer for developing better therapeutics for treatments of cancer and other diseases in which Src and Src family kinases are either highly elevated or genetically and/or functionally reduced.  These disease states include, but not limited to, leukemia, prostate and breast cancers, uremic cardiomyopathy, hypertension, cardiac fibrosis, and comprised myocardial contractility.

This patent application covers endotracheal tube device that is designed to safely stay in position after intubation.  The advanced design improves the stability of the endotracheal tube while in patients. It is a safe and reliable way to obtain and maintain a secure airway and is designed to decrease the risk of self-extubation or accidental extubation.

D2007-04

ECG and its derivatives as specific activators of pkc-epsilon

Patent Pending

This patent application covers compositions and methods for reducing the risk of congestive heart failure and, more particularly, to providing enhanced cardiac performance without raising intracellular calcium concentrations.

D2007-07

Genes in mice for regulating high blood pressure

Patent Pending

A system is provided for evaluating a parentally imprinted quantitative trait locus (QTL) or functional fragment derived thereof, where the QTL at least partially controls blood pressure and/or at least partially is indicative of a potential for developing a hypertensive disease.

D2007-09

Injectable biomimetic hybrid microparticles for bone regeneration

Patent Pending

D2007-11

Cortical Elisa for Fish

Patent Pending

Patent Pending

Patent Pending

This patent discloses a method of depositing a metal film on a silyl hydride surface of a solid such as silica gel, the solid normally having hydroxyl groups, the metal with a valence of zero being deposited on the surface by reaction of a metal ion in a solution with the hydrogens of the silyl hydrides. The above method is used to easily remove metal ions from a solution and also the method is a basis for determining the number of silyl hydride groups on the surface of the solid.

This patent application comprises an enhancement for dye-sensitized solar cells. Dye-sensitized solar cells (DSSCs) are a promising potential alternative to the high-cost solar cells that are currently on the market, such as silicon based and thin film devices. DSSCs may be far cheaper than competing technologies, but they are also much less efficient at converting solar energy into useful electrical energy. Herein is described a method for using colloidal metal nanoparticles to improve the conversion efficiency of dye-sensitized solar cells.

ENG00390

High Efficiency Voltage Converter

US Patent No.: 5,235,501

ENG00593

AC to DC Converter System with Ripple Feedback Circuit

US Patent No.: 5,237,492

Disclosures ENG00603 and ENG00803 cover a bearingless motor/generator (M/G) (note that this technology can be applied to a motor, a generator, or a motor/generator).  Potential applications for bearingless M/Gs include flywheels, turbines, pumps, and machine tools. M/Gs consist of a rotor (the rotating portion) and a stator (the stationary part, which generates the drive field to spin the rotor).  Typical M/Gs also have mechanical bearings, which hold the rotor in place while allowing it to spin freely.  Mechanical bearings have many disadvantages; they generate friction (and thus losses), compromise the performance of the M/G (limit motor speed and allowable operating temperature), require lubrication, and can cause motor failure through mechanical breakdown.  This patent describes a M/G design that will eliminate the need for mechanical bearings.

Disclosures ENG00603 and ENG00803 cover a bearingless motor/generator (M/G) (note that this technology can be applied to a motor, a generator, or a motor/generator).  Potential applications for bearingless M/Gs include flywheels, turbines, pumps, and machine tools. M/Gs consist of a rotor (the rotating portion) and a stator (the stationary part, which generates the drive field to spin the rotor).  Typical M/Gs also have mechanical bearings, which hold the rotor in place while allowing it to spin freely.  Mechanical bearings have many disadvantages; they generate friction (and thus losses), compromise the performance of the M/G (limit motor speed and allowable operating temperature), require lubrication, and can cause motor failure through mechanical breakdown.  This patent describes a M/G design that will eliminate the need for mechanical bearings.

ENG01105

Compressible Self-Distracting Joint Replacement Assembly

ENG00106

High Frame Rate Imaging System

ENG00306

Using Endogenous Polarization-Sensitive Fluorescence to Monitor Metabolic Changes in Living Cells

This invention provides a method for determining the state cell metabolism and evaluating the changes in fluorescence from endogenous fluorophores within the cell.

ENG00706

Heart Rate Synchronizing System

Integrated system for measuring and equalizing cell voltages in large batteries 

ENG01106

Artificial facet system for lumbar spine

ENG01206

Bioreactor for In Vitro Formation of the Nucleus Pulpuosus

ENG01306

Sulfur-Tolerant Catalysts and Synthesis Thereof

Patent Pending

Patent Pending

Patent Pending

Patent Pending

Patent Pending

Desulfurizer-Reformer Reactor System for use with Solid Oxide Fuel Cells 

Patent Pending

Method to Obtain Cellular RNA Substantially Free of Protein and DNA

Patent Pending

Patent Pending

Patent Pending

Method for Glycemic Forecasting

Patent Pending

Novel sulfate ester agents and the use of those agents for treating gastroesophageal reflux disease (GERD) are described, exemplary agents being of the formula: ##STR1## wherein X is --OCH.sub.2 -- or --CH.sub.2 O--; Y is a group pendant from X comprising at least one --OSO.sub.3 R.sup.4 moiety, wherein R.sup.4 is H or a pharmaceutically acceptable cation; n is an integer from 1-3; and R.sup.1 and R.sup.2 are each independently selected from the group consisting of --H, a halogen with an atomic number from 9 to 53, --SO.sub.3 R.sup.4, --NCS, --NCO, --NH(CO)--OR.sup.3, --NH(CS)SR.sup.3, --NH(C.dbd.NH)OR.sup.3, --NHCOCH.sub.2 Cl, --NHCOCH.sub.2 Br, --NHCO--CH.dbd.CH.sub.2, --NHC(O)--CF.sub.3, wherein R.sup.4 is H or a pharmaceutically acceptable cation.

Peptides and pharmaceutical compositions of matter useful as cytotoxic compositions particularly for, but not limited to, treatment of cancers, that includes a synthetic peptide whose amino acid sequence is different from an initial loop of cobra cardiotoxin.

This patent covers a method for removing acyl-groups appended by an ester linkage to the 2'-hydroxyl group present in paclitaxel-related molecules comprising treatment with alcohol under non-acidic conditions. 2',7-bis-Monochloroacetylpaclitaxel analogs are converted to their corresponding 7-monochloroacetyl derivatives by treatment with alcohol under non-acidic conditions ##STR1##

This patent application covers methods and compositions for treating cancer patients that include administering at least one or more hybrid derivatives of paclitaxel that simultaneously display improved aqueous solubility, chemical stability under physiological conditions, a decreased liability toward multi-drug resistance, and in certain instances enhanced selective toxicity toward cancer cells compared to normal cells. The derivative, paclitaxel substituted with at least one or more polar appendages at either the 7- or 10- positions as defined by a formula ?7-OR-10-OR?-paclitaxel?, is either deployed alone or in combination protocols with other chemotherapeutic agents.

PHR00107

Patent Pending

Changes in optical properties of layered materials are measured by directing an incident wave of finite transverse dimensions toward layered materials under conditions that will produce a propagating surface mode or a waveguide mode in the layered materials. The intensity distribution is measured within the transverse beam profile of the total reflected beam. The profile shows asymmetric structure associated with the excitation of the propagating surface mode or a wave-guide mode. The index of refraction of the layered materials is modified and the reshaped intensity distribution within the transverse beam profile of the total reflected beam is again measured under the same incidence conditions. The measured intensity distributions are compared to detect differences in the indexes of refraction in the layered materials.

A tunnel junction structure comprises an n-type tunnel junction layer of a first semiconductor material, a p-type tunnel junction layer of a second semiconductor material and a tunnel junction between the tunnel junction layers. The first semiconductor material includes gallium (Ga), nitrogen (N), arsenic (As) and is doped with a Group VI dopant. The probability of tunneling is significantly increased, and the voltage drop across the tunnel junction is consequently decreased, by forming the tunnel junction structure of materials having a reduced difference between the valence band energy of the material of the p-type tunnel junction layer and the conduction band energy of the n-type tunnel junction layer. Doping the first semiconductor material n-type with a Group VI dopant maximizes the doping concentration in the first semiconductor material, thus further improving the probability of tunneling.

A method of making a diode structure includes the step of depositing a transparent electrode layer of any one or more of the group ZnO, ZnS and CdO onto a substrate layer, and depositing an active semiconductor junction having an n-type layer and a p-type layer onto the transparent electrode layer under process conditions that avoid substantial degradation of the electrode layer. A back electrode coating layer is applied to form a diode structure.

A method for detecting magnetic nanoparticles includes using the plasmon enhancement of a magneto-optical (MO) response in at least one nanoparticle.

PHYS00106

Corrosion resistant electrodes and corrosion resistant protective tunneling layers

Patent Pending

The invention introduces a new concept and construction of corrosion protective layer based on amorphous film made of electrically insulating material.

Patent Pending